Anti-EIF4EBP1 Antibody BHA11302068

Mfr.No.	BS3613
Alternative Names	Eukaryotic translation initiation factor 4E-binding protein 1 ; 4E-BP1 ; eIF4E-binding protein 1 ; Phosphorylated heat- and acid-stable protein regulated by insulin 1 ; PHAS-I ; EIF4EBP1 ; 4EBP1 ; PHAS I ; PHASI
Categories	Primary Antibodies
Chromosome Location	8p11.23
Clonality	polyclonal
Description	The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 17-60 of Human 4E-BP1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: 4E-BP1 (G39) polyclonal antibody detects endogenous levels of 4E-BP1 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.