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Home / Primary Antibodies / Polyclonal Antibodies

Anti-EIF2S1 Antibody Picoband®

SKU : BHA21007249

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Mfr.No.	PA2029, PA2029-10ug, PA2029-Biotin, PA2029-Cy3, PA2029-Dylight488, PA2029-Dylight550, PA2029-Dylight594, PA2029-FITC, PA2029-HRP, PA2029-APC, PA2029-PE, PA2029-iFluor647, PA2029-carrier-free
Alternative Names	Eukaryotic translation initiation factor 2 subunit 1
Background	EIF2S1 (Eukaryotic Translation Initiation Factor 2, Subunit 1), also called EIF2-alpha, is a protein that in humans is encoded by the EIF2S1 gene. Hartz (2010) mapped the EIF2S1 gene to chromosome 14q23.3 based on an alignment of the EIF2S1 sequence with the genomic sequence (GRCh37). Est et al. (1987) stated that protein synthesis is inhibited due to phosphorylation of Eif2-alpha in hemin-deprived rabbit reticulocyte lysates. HeLa cells subjected to heat shock, serum deprivation, or interferon treatment followed by virus infection also show a correlation between EIF2-alpha phosphorylation and translational repression. Jacob et al. (1989) found that the alpha-Pal transcription factor bound to 2 palindromic sites within the EIF2-alpha promoter and was essential for transcription of the EIF2-alpha gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-EIF2S1 Antibody catalog # PA2029. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Functions in the early steps of protein synthesis by forming a teary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human EIF2S1.
Isotype	Rabbit IgG
Molecular Weight	94 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Eukaryotic translation initiation factor 2 subunit 1;Eukaryotic translation initiation factor 2 subunit alpha;eIF-2-alpha;eIF-2A;eIF-2alpha;EIF2S1;EIF2A;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P05198
Gene Name	EIF2S1
Sequence	Belongs to the eIF-2-alpha family.
Subcellular Location	Cytoplasmic granule . The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Est, H., Duncan, R. F., Hershey, J. W. B. Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2: characterization of the protein and its messenger RNA. J. Biol. Chem. 262: 1206-1212, 1987. <br /><br />2. Hartz, P. A. Personal Communication. Baltimore, Md. 1/28/2010. <br /><br />3. Jacob, W. F., Silverman, T. A., Cohen, R. B., Safer, B. Identification and characterization of a novel transcription factor participating in the expression of eukaryotic initiation factor 2 alpha. J. Biol. Chem. 264: 20372-20384, 1989.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007249-1	PA2029	-	100 ug	$370		Add to Cart
BHA21007249-2	PA2029-10ug	Sample	10 ug	$99		Add to Cart
BHA21007249-3	PA2029-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007249-4	PA2029-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007249-5	PA2029-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007249-6	PA2029-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007249-7	PA2029-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007249-8	PA2029-FITC	FITC	100 ug	$570		Add to Cart
BHA21007249-9	PA2029-HRP	HRP	100 ug	$570		Add to Cart
BHA21007249-10	PA2029-APC	APC	100 ug	$670		Add to Cart
BHA21007249-11	PA2029-PE	PE	100 ug	$670		Add to Cart
BHA21007249-12	PA2029-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007249-13	PA2029-carrier-free	carrier-free	100 ug	$370		Add to Cart

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