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Home / Primary Antibodies / IHC Antibodies

Anti-EGR2/EGR1 Antibody BHA11301035

SKU : BHA11301035

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Mfr.No.	BS1944
Alternative Names	Early growth response protein 1 ; EGR-1 ; AT225 ; Nerve growth factor-induced protein A ; NGFI-A ; Transcription factor ETR103 ; Transcription factor Zif268 ; Zinc finger protein 225 ; Zinc finger protein Krox-24 ; EGR1 ; KROX24 ; ZNF225 ; E3 SUMO-protein ligase EGR2 ; AT591 ; Early growth response protein 2 ; EGR-2 ; Zinc finger protein Krox-20 ; EGR2 ; KROX20
Categories	Primary Antibodies
Clonality	polyclonal
Description	Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. The deduced amino acid sequences of human Egr-2 and mouse Egr-1 are 92% identical in the zinc finger region but show no homology elsewhere. Egr-2 is a sequence-specific DNA-binding transcription factor that binds two specific DNA sites located in the promoter region of HoxA4 and localizes to the nucleus. Defects in the Egr-2 protein are a cause of congenital hypomyelination neuropathy (CHN). CHN is characterized clinically by early onset of hypotonia, areflexia, distal muscle weakness and very slow nerve conduction velocities. Mutations in the gene that encodes Egr-2 (EGR2) also cause of Dejerine-Sottas syndrome (DSS), which is also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS patients exhibit severe early onset motor and sensory neuropathy with very slow nerve conduction velocities and elevated cerebrospinal fluid protein concentrations.
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to amino acids 370-420 of Human Egr-1.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO

Swissprot	P18146/P11161
Uniprot	P18146/P11161
Weight	50 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: Egr-2 (R409) polyclonal antibody detects endogenous levels of Egr-2 protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC, IF

Description

WB ; IHC ; IF

Dilution

WB	1:500-1:1000
IHC	1:50-1:200
IF	1:50-1:200

Datasheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301035	BS1944	50µl	$190.44		Add to Cart
BHA11301035	BS1944	100µl	$294.44		Add to Cart

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