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Home / Primary Antibodies / Polyclonal Antibodies

Anti-EGFR Antibody Picoband®

SKU : BHA21007479

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Mfr.No.	PB9016, PB9016-10ug, PB9016-Biotin, PB9016-Cy3, PB9016-Dylight488, PB9016-Dylight550, PB9016-Dylight594, PB9016-FITC, PB9016-HRP, PB9016-APC, PB9016-PE, PB9016-iFluor647, PB9016-carrier-free
Alternative Names	Epidermal growth factor receptor
Background	The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGFalpha). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to EGFR over[removed]known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-EGFR Antibody Picoband® catalog # PB9016. Tested in IF, ICC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin,
Host	Rabbit
Immunogen Region	E.coli-derived human EGFR recombinant protein (Position: L25-K346). Human EGFR shares 89% amino acid (aa) sequence identity with mouse EGFR.
Isotype	Rabbit IgG
Molecular Weight	200 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Epidermal growth factor receptor;2.7.10.1;Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1;EGFR;ERBB, ERBB1, HER1;
Tissue Specificity	Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P00533
Gene Id	1956
Gene Name	EGFR
Sequence	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome. Endosome membrane. Nucleus. In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF).

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat<br> Immunocytochemistry/Immunofluorescence, 2ug/ml, Human<br>

Reference	1. Herbst RS (2004). "Review of epidermal growth factor receptor biology". Int. J. Radiat. Oncol. Biol. Phys. 59 (2 Suppl): 216.<br /><br />2. Wang, K.; Yamamoto, H.; Chin, J. R.; Werb, Z.; Vu, T. H.: Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J. Biol. Chem. 279: 53848-53856, 2004.<br /><br />3. Kuan CT, Wikstrand CJ, Bigner DD (June 2001). "EGF mutant receptor vIII as a molecular target in cancer therapy". Endocr. Relat. Cancer 8 (2): 8396.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007479-1	PB9016	-	100 ug	$370		Add to Cart
BHA21007479-2	PB9016-10ug	Sample	10 ug	$99		Add to Cart
BHA21007479-3	PB9016-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007479-4	PB9016-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007479-5	PB9016-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007479-6	PB9016-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007479-7	PB9016-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007479-8	PB9016-FITC	FITC	100 ug	$570		Add to Cart
BHA21007479-9	PB9016-HRP	HRP	100 ug	$570		Add to Cart
BHA21007479-10	PB9016-APC	APC	100 ug	$670		Add to Cart
BHA21007479-11	PB9016-PE	PE	100 ug	$670		Add to Cart
BHA21007479-12	PB9016-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007479-13	PB9016-carrier-free	carrier-free	100 ug	$370		Add to Cart

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