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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Dysferlin/DYSF Antibody Picoband®

SKU : BHA21003341

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Mfr.No.	A01234-3, A01234-3-10ug, A01234-3-Biotin, A01234-3-Cy3, A01234-3-Dylight488, A01234-3-Dylight550, A01234-3-Dylight594, A01234-3-FITC, A01234-3-HRP, A01234-3-APC, A01234-3-PE, A01234-3-iFluor647, A01234-3-carrier-free
Alternative Names	histone deacetylase 5
Background	Dysferlin also known as dystrophy-associated fer-1-like protein is a protein that in humans is encoded by the DYSF gene. The protein encoded by this gene belongs to the ferlin family and is a skeletal muscle protein found associated with the sarcolemma. It is involved in muscle contraction and contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. In addition, the protein encoded by this gene binds caveolin-3, a skeletal muscle membrane protein which is important in the formation of caveolae. Specific mutations in this gene have been shown to cause autosomal recessive limb girdle muscular dystrophy type 2B (LGMD2B) as well as Miyoshi myopathy. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Dysferlin/DYSF Antibody Picoband® catalog # A01234-3. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progr
Host	Rabbit
Immunogen Region	E.coli-derived human DYSF recombinant protein (Position: E51-H747).
Isotype	Rabbit IgG
Molecular Weight	280 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Histone deacetylase 5; HD5; Antigen NY-CO-9; HDAC5; KIAA0600
Tissue Specificity	Ubiquitous.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	O75923
Gene Id	8291
Gene Name	DYSF
Subcellular Location	Nucleus. Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Mouse<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Anderson, L. V. B., Davison, K., Moss, J. A., Young, C., Cullen, M. J., Walsh, J., Johnson, M. A., Bashir, R., Britton, S., Keers, S., Argov, Z., Mahjneh, I., Fougerousse, F., Beckmann, J. S., Bushby, K. M. D. Dysferlin is a plasma membrane protein and is expressed early in human development. Hum. Molec. Genet. 8: 855-861, 1999. Note: Erratum: Hum. Molec. Genet. 8: 1141 only, 1999. <br /><br />2. Aoki, M., Liu, J., Richard, I., Bashir, R., Britton, S., Keers, S. M., Oeltjen, J., Brown, H. E., Marchand, S., Bourg, N., Beley, C., McKenna-Yasek, D., and 13 others. Genomic organization of the dysferlin gene and novel mutations in Miyoshi myopathy. Neurology 57: 271-278, 2001.<br /><br />3. Bansal, D., Miyake, K., Vogel, S. S., Groh, S., Chen, C.-C., Williamson, R., McNeil, P. L., Campbell, K. P. Defective membrane repair in dysferlin-deficient muscular dystrophy. Nature 423: 168-172, 2003.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003341-1	A01234-3	-	100 ug	$370		Add to Cart
BHA21003341-2	A01234-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21003341-3	A01234-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003341-4	A01234-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003341-5	A01234-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003341-6	A01234-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003341-7	A01234-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003341-8	A01234-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21003341-9	A01234-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21003341-10	A01234-3-APC	APC	100 ug	$670		Add to Cart
BHA21003341-11	A01234-3-PE	PE	100 ug	$670		Add to Cart
BHA21003341-12	A01234-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003341-13	A01234-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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