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Home / Primary Antibodies / IHC Antibodies

Anti-DMPK Antibody BHA11301290

SKU : BHA11301290

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Mfr.No.	BS2298
Alternative Names	Myotonin-protein kinase ; MT-PK ; DM-kinase ; DMK ; DM1 protein kinase ; DMPK ; Myotonic dystrophy protein kinase ; DMPK ; DM1PK ; MDPK
Antigen	DMPK
Categories	Primary Antibodies
Chromosome Location	19q13.32
Clonality	polyclonal
Description	Myotonic dystrophy protein kinase (DMPK) is a ulti-domain protein kinase found in muscle that is activated in response to G protein second messengers and proteolysis. DMPK is implicated in myotonic muscular dystrophy (DM), an autosomal dominant-inherited disorder that predominately affects skeletal and cardiac muscle and causes defects in cardiac conduction. DM arises through expansion of CTG repeats in the 3’-UTR of the DMPK gene. Mutant DMPK transcripts with an extended region of CUG repeats are retained in the nucleus. These transcripts also influence the expression of the DM locus-associated homeodomain protein (DMAHP)/SIX5, to mediate in part the DM phenotype. Other substrates for DMPK include myogenin, Ltype calcium channels, and Phospholemman (PLM).
Host	Rabbit
Immunogen	Synthetic peptide, corresponding to the N-terminus of Human DMPK.
Reactivity	Human, Mouse, Rat
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)

Swissprot	Q09013
Uniprot	Q09013
Weight	70 kDa

Description	Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. Specificity: DMPK (R30) polyclonal antibody detects endogenous levels of DMPK protein.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Applications

WB, IHC

Description

WB ; IHC

Dilution

WB	1:500-1:1000
IHC	1:50-1:200

Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA11301290	BS2298	50µl	$190.44		Add to Cart
BHA11301290	BS2298	100µl	$294.44		Add to Cart

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