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Home / Primary Antibodies / Monoclonal Antibodies

Anti-DLL3-Anti-CD3 Bispecific Molecule

SKU : BHA18200128

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BPS Bioscience

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Mfr.No.	102209, 102209-1, 102209-2
Background	DLL3, also known as delta like ligand three, is a Notch ligand characterized by a DSL domain, transmembrane region, and a series of EGF repeats. Notch ligands can participate in trans-interactions (interaction with Notch receptor on a different cell) and cis interactions (interaction with Notch receptor within the same cell) to activate or inhibit Notch signaling, respectively. DLL3 exclusively functions to inhibit Notch signaling through cis inhibition. While DLL3 expression is limited in healthy tissue, high expression levels of DLL3 are found in various cancers including small cell lung cancer (SCLC), where it plays an oncogenic role. Relieving DLL3-mediated inhibition of Notch signaling may serve as a therapeutic avenue, with drugs being developed to target DLL3 as a possible lung cancer therapy (example: rovalpituzumab tesirine).
Clonality	Monoclonal
Description	Anti-DLL3-Anti-CD3 Bispecific Molecule is a purified recombinant human bispecific molecule with T cell Engager. This bispecific molecule has been tested for specific activity in a functional reporter assay using NFAT Luciferase Reporter Jurkat Cell Line (BPS Bioscience #60621) co-cultured with DLL3 CHO Cell Line.
Formulation	8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Host	HEK293
Isotype	IgG1
Molecular Weight	105 kDa + glycans
Shipping	-80°C
Species	Human
Synonyms	Drosophila Delta homolog 3 (Delta3), Delta-like protein 3
Usage	Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles.
Note	Waings Avoid freeze/thaw cycles Scientific Category Immunotherapy Regulatory Status Research Use Only

Uniprot	DLL3: Q9NYJ7

Format	Aqueous buffer solution
Purity	≥90%
Storage	At least 12 months at -80°C.

Tested Application	The Anti-DLL3-Anti-CD3 Bispecific Molecule can be used for studying DLL3+ cancer cell-mediated T cell activation, using either primary T cells or reporter cell lines such NFAT Luciferase Reporter Jurkat Cell Line.

Product Manual	102209 Lot 240404

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA18200128-1	102209-1	50 µg	$410		Add to Cart
BHA18200128-2	102209-2	100 µg	$560		Add to Cart

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