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Home / Primary Antibodies / Monoclonal Antibodies

Anti-Cytokeratin 5

SKU : BHA15100316

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Mfr.No.	AN853-5M
Clonality	Monoclonal
Description	Cytokeratins are intermediate filament proteins expressed in cytoplasm of epithelial cells. The mitotically active basal layers of most stratified squamous epithelia express 10% to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin CK5 and type I keratin CK14, which essentially form 8-nm filaments. CK5 and calretinin are useful immunohistochemical markers in different studies of mesothelioma, and their expression is key tool for the histological differential diagnosis with adenocarcinomas, especially when confronting with metastatic tumors of unknown origin. CK5 labels myoepithelial cells of breast and prostate basal cells. A combination of CK5, CK14 and p63, has been used as specific and sensitive cell marker of basal-like phenotype of breast carcinoma and to differentiate prostate cancer and normal cells. Loss-of- function mutations in the keratin 5 gene (KRT5) affected family members and in six unrelated patients with Dowling-Degos disease (DDD), an autosomal dominant genodermatosis. This indicates a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage.
Host	Rabbit
Isotype	IgG
Reactivity	Human
Species	Rabbit

Clone No	EP42
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:50-100

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AN853-5M	AN853-5M	6 mL	$339		Add to Cart
AN853-10M	AN853-10M	100 tests - i6000	$608		Add to Cart
AY853-50D	AY853-50D	50 tests - Xmatrx	$361		Add to Cart
AY853-YCD	AY853-YCD	160 tests - Xmatrx	$973		Add to Cart
NU853-UC	NU853-UC	1ml Conc	$489		Add to Cart
NU853-5UC	NU853-5UC	0.5ml Conc	$339		Add to Cart

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