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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cyclin-dependent kinase 1 CDK1 Antibody Picoband®

SKU : BHA21006875

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Mfr.No.	PA1544, PA1544-10ug, PA1544-Biotin, PA1544-Cy3, PA1544-Dylight488, PA1544-Dylight550, PA1544-Dylight594, PA1544-FITC, PA1544-HRP, PA1544-APC, PA1544-PE, PA1544-iFluor647, PA1544-carrier-free
Alternative Names	Cyclin-dependent kinase 1
Background	CDC2, Cell Division Cycle 2, is also known as CDK1 (Cyclin-dependent Kinase 1). CDC2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells CDC2 is the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell cycle regulation. CDC2 gene is located on chromosome 10.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cyclin-dependent kinase 1 CDK1 Antibody catalog # PA1544. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human CDK1, different from the relative rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	34 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cyclin-dependent kinase 1;CDK1;2.7.11.22;2.7.11.23;Cell division control protein 2 homolog;Cell division protein kinase 1;p34 protein kinase;CDK1;CDC2, CDC28A, CDKN1, P34CDC2;
Tissue Specificity	Isoform 2 is found in breast cancer tissues.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P06493
Gene Name	CDK1
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Subcellular Location	Nucleus. Cytoplasm. Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin- B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Draetta, G.; Piwnica-Worms, H.; Morrison, D.; Druker, B.; Roberts, T.; Beach, D. : Human CDC2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature 336: 738-744, 1988.<br /><br />2. Spurr, N. K.; Goodfellow, P. N.; Nurse, P.; Lee, M. : Assignment of the human homologue of the yeast cell cycle control gene CDC2 to chromosome 10. (Abstract) Cytogenet. Cell Genet. 46: 698, 1987.<br /><br />3. Nazarenko, S. A.; Ostroverhova, N. V.; Spurr, N. K. : Regional assignment of the human cell cycle control gene CDC2 to chromosome 10q21 by in situ hybridization. Hum. Genet. 87: 621-622, 1991. <br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006875-1	PA1544	-	100 ug	$370		Add to Cart
BHA21006875-2	PA1544-10ug	Sample	10 ug	$99		Add to Cart
BHA21006875-3	PA1544-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006875-4	PA1544-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006875-5	PA1544-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006875-6	PA1544-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006875-7	PA1544-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006875-8	PA1544-FITC	FITC	100 ug	$570		Add to Cart
BHA21006875-9	PA1544-HRP	HRP	100 ug	$570		Add to Cart
BHA21006875-10	PA1544-APC	APC	100 ug	$670		Add to Cart
BHA21006875-11	PA1544-PE	PE	100 ug	$670		Add to Cart
BHA21006875-12	PA1544-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006875-13	PA1544-carrier-free	carrier-free	100 ug	$370		Add to Cart

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