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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CXCR4 Antibody Picoband®

SKU : BHA21006694

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Mfr.No.	PA1237, PA1237-10ug, PA1237-Biotin, PA1237-Cy3, PA1237-Dylight488, PA1237-Dylight550, PA1237-Dylight594, PA1237-FITC, PA1237-HRP, PA1237-APC, PA1237-PE, PA1237-iFluor647, PA1237-carrier-free
Alternative Names	C-X-C chemokine receptor type 4
Background	CXCR4 (Chemokine,CXC Motif, Receptor 4), also known as FUSIN or NPY3R, is a protein that in humans is encoded by the CXCR4 gene. It is the receptor for the CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological functions and T lymphocyte trafficking. CXCR4 is the only SDF1 receptor identified so far. This suggests that CXCR4 expression is critical for the biological effects of SDF1. CXCR4 is also a seven-transmembrane-spanning, G-protein-coupled receptor for the CXC chemokine PBSF/SDF-1. It functions as a co-receptor for T-cell-line tropic human immunodeficiency virus HIV-1. It was concluded that PBSF/SDF-1 and CXCR4 define a new signalling system for organ vascularization.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CXCR4 Antibody catalog # PA1237. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CXCR4, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	40-43 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-X-C chemokine receptor type 4;CXC-R4;CXCR-4;FB22;Fusin;HM89;LCR1;Leukocyte-derived seven transmembrane domain receptor;LESTR;Lipopolysaccharide-associated protein 3;LAP-3;LPS-associated protein 3;NPYRL;Stromal cell-derived factor 1 receptor;SDF-1 receptor;CD184;CXCR4;
Tissue Specificity	Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P61073
Gene Name	CXCR4
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. In unstimulated cells, diffuse patte on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Caruz, A.; Samsom, M.; Alonso, J. M.; Alcami, J.; Baleux, F.; Virelizier, J. L.; Parmentier, M.; Arenzana-Seisdedos, F. : Genomic organization and promoter characterization of human CXCR4 gene. FEBS Lett. 426: 271-278, 1998. <br /><br />2. Tachibana, K.; Hirota, S.; Iizasa, H.; Yoshida, H.; Kawabata, K.; Kataoka, Y.; Kitamura, Y.; Matsushima, K.; Yoshida, N.; Nishikawa, S.; Kishimoto, T.; Nagasawa, T. : The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393: 591-594, 1998.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006694-1	PA1237	-	100 ug	$370		Add to Cart
BHA21006694-2	PA1237-10ug	Sample	10 ug	$99		Add to Cart
BHA21006694-3	PA1237-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006694-4	PA1237-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006694-5	PA1237-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006694-6	PA1237-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006694-7	PA1237-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006694-8	PA1237-FITC	FITC	100 ug	$570		Add to Cart
BHA21006694-9	PA1237-HRP	HRP	100 ug	$570		Add to Cart
BHA21006694-10	PA1237-APC	APC	100 ug	$670		Add to Cart
BHA21006694-11	PA1237-PE	PE	100 ug	$670		Add to Cart
BHA21006694-12	PA1237-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006694-13	PA1237-carrier-free	carrier-free	100 ug	$370		Add to Cart

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