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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cullin 4B/CUL4B Antibody Picoband®

SKU : BHA21006691

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Mfr.No.	PA1233, PA1233-10ug, PA1233-Biotin, PA1233-Cy3, PA1233-Dylight488, PA1233-Dylight550, PA1233-Dylight594, PA1233-FITC, PA1233-HRP, PA1233-APC, PA1233-PE, PA1233-iFluor647, PA1233-carrier-free
Alternative Names	Cullin-4B
Background	Cullin 4B/CUL4B encodes a scaffold protein that organizes a cullin-RING (really interesting new gene) ubiquitin ligase (E3) complex in ubiquitylation. The CUL4 gene encodes a protein of 913 amino acids. The cullin domain is located between amino acid residues 217 and 815 and is characterized a by C-terminal globular domain (cullin homology domain) and a series of N-terminal repeats (cullin repeats). Ohtake et al. (2007) characterize a fat-soluble ligand-dependent ubiquitin ligase complex in human cell lines, in which dioxin receptor (AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B (AhR). Complex assembly and ubiquitin ligase activity of CUL4B (AhR) in vitro and in vivo are dependent on the AhR ligand. In the CUL4B (AhR) complex, ligand-activated AhR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Their findings uncover a function for AhR as an atypical component of the ubiquitin ligase complex and demonstrate a non-genomic signalling pathway in which fat-soluble ligands regulate target-protein-selective degradation through a ubiquitin ligase complex.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cullin 4B/CUL4B Antibody catalog # PA1233. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat, Zebrafish. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Cullin 4B, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	104 kDa
Reactivity	Human, Mouse, Rat, Zebrafish
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cullin-4B;CUL-4B;CUL4B;KIAA0695;
Tissue Specificity	Bcl-X (S) is expressed at high levels in cells that undergo a high rate of tuover, such as developing lymphocytes. In contrast, Bcl-X (L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q13620
Gene Name	CUL4B
Sequence	Belongs to the cullin family.
Subcellular Location	Nucleus .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Zebrafish, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Rat, Zebrafish, Mouse<br>

Reference	1. Zou, Y.; Liu, Q.; Chen, B.; Zhang, X.; Guo, C.; Zhou, H.; Li, J.; Gao, G.; Guo, Y.; Yan, C.; Wei, J.; Shao, C.; Gong, Y. : Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation. Am. J. Hum. Genet. 80: 561-566, 2007. <br /><br />2. Tarpey, P. S.; Raymond, F. L.; O'Meara, S.; Edkins, S.; Teague, J.; Butler, A.; Dicks, E.; Stevens, C.; Tofts, C.; Avis, T.; Barthorpe, S.; Buck, G. : {and 41 others}: Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor. Am. J. Hum. Genet. 80: 345-352, 2007. <br /><br />3. Ohtake, F.; Baba, A.; Takada, I.; Okada, M.; Iwasaki, K.; Miki, H.; Takahashi, S.; Kouzmenko, A.; Nohara, K.; Chiba, T.; Fujii-Kuriyama, Y.; Kato, S. : Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446: 562-566, 2007.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006691-1	PA1233	-	100 ug	$370		Add to Cart
BHA21006691-2	PA1233-10ug	Sample	10 ug	$99		Add to Cart
BHA21006691-3	PA1233-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006691-4	PA1233-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006691-5	PA1233-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006691-6	PA1233-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006691-7	PA1233-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006691-8	PA1233-FITC	FITC	100 ug	$570		Add to Cart
BHA21006691-9	PA1233-HRP	HRP	100 ug	$570		Add to Cart
BHA21006691-10	PA1233-APC	APC	100 ug	$670		Add to Cart
BHA21006691-11	PA1233-PE	PE	100 ug	$670		Add to Cart
BHA21006691-12	PA1233-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006691-13	PA1233-carrier-free	carrier-free	100 ug	$370		Add to Cart

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