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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CSEN/KCNIP3 Antibody Picoband®

SKU : BHA21007437

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Mfr.No.	PA2272, PA2272-10ug, PA2272-Biotin, PA2272-Cy3, PA2272-Dylight488, PA2272-Dylight550, PA2272-Dylight594, PA2272-FITC, PA2272-HRP, PA2272-APC, PA2272-PE, PA2272-iFluor647, PA2272-carrier-free
Alternative Names	Calsenilin
Background	KCNIP3, also known as Calsenilin, is a calcium-dependent transcriptional repressor that is highly expressed in central nervous system, thyroid gland, testis, thymus, and immune cells. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. KCNIP3 is mapped to 2q11.1. The encoded protein functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. KCNIP3-regulated genes have a critical function in Ig subclass production and proliferation in B lymphocytes. KCNIP3 has been shown to interact with PSEN1 and PSEN2.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CSEN/KCNIP3 Antibody catalog # PA2272. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human CSEN.
Isotype	Rabbit IgG
Molecular Weight	29 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Calsenilin;A-type potassium channel modulatory protein 3;DRE-antagonist modulator;DREAM;Kv channel-interacting protein 3;KChIP3;KCNIP3;CSEN, DREAM, KCHIP3;
Tissue Specificity	Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9Y2W7
Gene Name	KCNIP3
Sequence	Belongs to the recoverin family.
Subcellular Location	Cytoplasm . Cell membrane ; Lipid-anchor . Endoplasmic reticulum . Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Carrion AM, Link WA, Ledo F, Mellstrom B, Naranjo JR (March 1999). "DREAM is a Ca2+-regulated transcriptional repressor".Nature 398 (6722): 804.<br /><br />2. "Entrez Gene: KCNIP3 Kv channel interacting protein 3, calsenilin"<br /><br />3. Savignac, M., Mellstrom, B., Bebin, A.-G., Oliveros, J. C., Delpy, L., Pinaud, E., Naranjo, J. R. Increased B cell proliferation and reduced Ig production in DREAM transgenic mice. J. Immun. 185: 7527-7536, 2010.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007437-1	PA2272	-	100 ug	$370		Add to Cart
BHA21007437-2	PA2272-10ug	Sample	10 ug	$99		Add to Cart
BHA21007437-3	PA2272-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007437-4	PA2272-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007437-5	PA2272-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007437-6	PA2272-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007437-7	PA2272-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007437-8	PA2272-FITC	FITC	100 ug	$570		Add to Cart
BHA21007437-9	PA2272-HRP	HRP	100 ug	$570		Add to Cart
BHA21007437-10	PA2272-APC	APC	100 ug	$670		Add to Cart
BHA21007437-11	PA2272-PE	PE	100 ug	$670		Add to Cart
BHA21007437-12	PA2272-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007437-13	PA2272-carrier-free	carrier-free	100 ug	$370		Add to Cart

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