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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Collagen II/COL2A1 Antibody Picoband®

SKU : BHA21007343

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Mfr.No.	PA2141, PA2141-10ug, PA2141-Biotin, PA2141-Cy3, PA2141-Dylight488, PA2141-Dylight550, PA2141-Dylight594, PA2141-FITC, PA2141-HRP, PA2141-APC, PA2141-PE, PA2141-iFluor647, PA2141-carrier-free
Alternative Names	Collagen alpha-1(II) chain
Background	Collagen, type II, alpha 1, also known as COL2A1, is a human gene which is the major collagen synthesized by chondrocvtes. COL2A1 is mapped to 12q13.11. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Collagen II/COL2A1 Antibody catalog # PA2141. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Collagen II, different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	170 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Collagen alpha-1 (II) chain;Alpha-1 type II collagen;Collagen alpha-1 (II) chain;Chondrocalcin;COL2A1;
Tissue Specificity	Isoform 2 is highly expressed in juvenile chondrocyte and low in fetal chondrocyte. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P02458
Gene Name	COL2A1
Sequence	Belongs to the fibrillar collagen family.
Subcellular Location	Secreted, extracellular space, extracellular matrix .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Donahue, L. R., Chang, B., Mohan, S., Miyakoshi, N., Wergedal, J. E., Baylink, D. J., Hawes, N. L., Rosen, C. J., Ward-Bailey, P., Zheng, Q. Y., Bronson, R. T., Johnson, K. R., Davisson, M. T. A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis. J. Bone Miner. Res. 18: 1612-1621, 2003. Note: Erratum: J. Bone Miner. Res. 22: 2011 only, 2007.<br /><br />2. Faivre, L., Le Merrer, M., Douvier, S., Laurent, N., Thauvin-Robinet, C., Rousseau, T., Vereecke, I., Sagot, P., Delezoide, A.-L., Coucke, P., Mortier, G. Recurrence of achondrogenesis type II within the same family: evidence for germline mosaicism. Am. J. Med. Genet. 126A: 308-312, 2004.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007343-1	PA2141	-	100 ug	$370		Add to Cart
BHA21007343-2	PA2141-10ug	Sample	10 ug	$99		Add to Cart
BHA21007343-3	PA2141-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007343-4	PA2141-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007343-5	PA2141-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007343-6	PA2141-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007343-7	PA2141-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007343-8	PA2141-FITC	FITC	100 ug	$570		Add to Cart
BHA21007343-9	PA2141-HRP	HRP	100 ug	$570		Add to Cart
BHA21007343-10	PA2141-APC	APC	100 ug	$670		Add to Cart
BHA21007343-11	PA2141-PE	PE	100 ug	$670		Add to Cart
BHA21007343-12	PA2141-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007343-13	PA2141-carrier-free	carrier-free	100 ug	$370		Add to Cart

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