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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CNTF Antibody Picoband®

SKU : BHA21007523

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Mfr.No.	PB9067, PB9067-10ug, PB9067-Biotin, PB9067-Cy3, PB9067-Dylight488, PB9067-Dylight550, PB9067-Dylight594, PB9067-FITC, PB9067-HRP, PB9067-APC, PB9067-PE, PB9067-iFluor647, PB9067-carrier-free
Alternative Names	Ciliary neurotrophic factor
Background	Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene. The protein encoded by this gene is a polypeptide hormone andnerve growth factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations includingastrocytes. It is mapped to 11q12.1. In addition to neurotrophic effects on parasympathetic neurons, CNTF was shown to have activities on sympathetic and sensory neurons. CNTF appears not to be involved in motor neuron survival during development. human CNTF has a trophic influence on degenerating striatal neurons as well as on critical nonstriatal regions. CNTF plays a role in a cardiac signal transduction pathway that regulates obesity-related left ventricular hypertrophy.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CNTF Antibody Picoband® catalog # PB9067. Tested in ELISA, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Host	Rabbit
Immunogen Region	E. coli-derived rat CNTF recombinant protein (Position: A2-M200). Rat CNTF shares 84% and 95% amino acid (aa) sequences identity with human and mouse CNTF, respectively.
Isotype	Rabbit IgG
Molecular Weight	23 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Ciliary neurotrophic factor;CNTF;Cntf;
Tissue Specificity	Nervous system.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P20294
Gene Id	25707
Gene Name	CNTF
Sequence	Belongs to the intercrine beta (chemokine CC) family.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	ELISA, 0.1-0.5ug/ml, - Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, By Heat Weste blot, 0.1-0.5ug/ml, Rat

Reference	1. Barbin, G., Manthorpe, M., Varon, S. Purification of the chick eye ciliary neuronotrophic factor. J. Neurochem. 43: 1468-1478, 1984. 2. Raju, S. V. Y., Zheng, M., Schuleri, K. H., Phan, A. C., Bedja, D., Saraiva, R. M., Yiginer, O., Vandegaer, K., Gabrielson, K. L., O'Donnell, C. P., Berkowitz, D. E., Barouch, L. A., Hare, J. M. Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. Proc. Nat. Acad. Sci. 103: 4222-4227, 2006. 3. Sendtner, M., Schmalbruch, H., Stockli, K. A., Carroll, P., Kreutzberg, G. W., Thoenen, H.Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358: 502-504, 1992. 4. Emerich, D. F., Winn, S. R., Hantraye, P. M., Peschanski, M., Chen, E.-Y., Chu, Y., McDermott, P., Baetge, E. E., Kordower, J. H. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease.Nature 386: 395-399, 1997.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007523-1	PB9067	-	100 ug	$370		Add to Cart
BHA21007523-2	PB9067-10ug	Sample	10 ug	$99		Add to Cart
BHA21007523-3	PB9067-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007523-4	PB9067-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007523-5	PB9067-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007523-6	PB9067-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007523-7	PB9067-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007523-8	PB9067-FITC	FITC	100 ug	$570		Add to Cart
BHA21007523-9	PB9067-HRP	HRP	100 ug	$570		Add to Cart
BHA21007523-10	PB9067-APC	APC	100 ug	$670		Add to Cart
BHA21007523-11	PB9067-PE	PE	100 ug	$670		Add to Cart
BHA21007523-12	PB9067-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007523-13	PB9067-carrier-free	carrier-free	100 ug	$370		Add to Cart

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