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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CHD8 Antibody Picoband®

SKU : BHA21005469

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Mfr.No.	A01346-1, A01346-1-10ug, A01346-1-Biotin, A01346-1-Cy3, A01346-1-Dylight488, A01346-1-Dylight550, A01346-1-Dylight594, A01346-1-FITC, A01346-1-HRP, A01346-1-APC, A01346-1-PE, A01346-1-iFluor647, A01346-1-carrier-free
Alternative Names	glutamate metabotropic receptor 5
Background	Chromodomain-helicase-DNA-binding protein 8 is an enzyme that in humans is encoded by the CHD8 gene. This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CHD8 Antibody Picoband® catalog # A01346-1. Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinosi
Host	Rabbit
Immunogen Region	E.coli-derived human CHD8 recombinant protein (Position: D10-A428).
Isotype	Rabbit IgG
Molecular Weight	300 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Metabotropic glutamate receptor 5; mGluR5; GRM5; GPRC1E, MGLUR5
Tissue Specificity	Isoform 1 and isoform 2 are detected in bone marrow cells, spermatogonia and spermatocytes, but not in round spermatids, elongating spermatids and spermatozoa. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa, but not in spermatogonia and spermatocytes (at protein level). Isoform 1 is widely expressed and detected in fetal liver and bone marrow. Isoform 3 is detected in bone marrow cells enriched in hematopoietic stem cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q9HCK8
Gene Id	57680
Gene Name	CHD8

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. An, Y., Zhang, L., Liu, W., Jiang, Y., Chen, X., Lan, X., Li, G., Hang, Q., Wang, J., Gusella, J. F., Du, Y., Shen, Y. De novo variants in the helicase-C domain of CHD8 are associated with severe phenotypes including autism, language disability and overgrowth. Hum. Genet. 139: 499-512, 2020. <br /><br />2. Batsukh, T., Pieper, L., Koszucka, A. M., von Velsen, N., Hoyer-Fender, S., Elbracht, M., Bergman, J. E. H., Hoefsloot, L. H., Pauli, S. CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome. Hum. Molec. Genet. 19: 2858-2866, 2010. <br /><br />3. Douzgou, S., Liang, H. W., Metcalfe, K., Somarathi, S., Tischkowitz, M., Mohamed, W., Kini, U., McKee, S., Yates, L., Bertoli, M., Lynch, S. A., Holder, S., the Deciphering Developmental Disorders Study, Banka, S. The clinical presentation caused by truncating CHD8 variants. Clin. Genet. 96: 72-84, 2019.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005469-1	A01346-1	-	100 ug	$370		Add to Cart
BHA21005469-2	A01346-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21005469-3	A01346-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005469-4	A01346-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005469-5	A01346-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005469-6	A01346-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005469-7	A01346-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005469-8	A01346-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21005469-9	A01346-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21005469-10	A01346-1-APC	APC	100 ug	$670		Add to Cart
BHA21005469-11	A01346-1-PE	PE	100 ug	$670		Add to Cart
BHA21005469-12	A01346-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005469-13	A01346-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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