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Home / Primary Antibodies / Monoclonal Antibodies

Anti-CDK1 Antibody (Monoclonal, A17)

SKU : BHA21006547

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Mfr.No.	MA1077
Alternative Names	Cyclin-dependent kinase 1
Background	P34 (cdc2), also known as cell division cycle (CDC2), or cyclin-dependent kinase 1 (CDK1). CDC2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells CDC2 is the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell cycle regulation. CDC2 gene is located on chromosome 10.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CDK1 Antibody (Monoclonal, A17) catalog # MA1077. Tested in IHC, WB applications. This antibody reacts with Chicken, Human, Mouse.
Function	Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in
Host	Mouse
Immunogen Region	C-terminal two-thirds of Xenopus CDK1 expressed in E.coli.
Isotype	Mouse IgG2a
Molecular Weight	18 kDa
Reactivity	Chicken, Human, Mouse
Reconstitution	Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cyclin-dependent kinase 1;CDK1;2.7.11.22;2.7.11.23;Cell division control protein 2 homolog;Cell division protein kinase 1;p34 protein kinase;Cdk1;Cdc2, Cdc2a, Cdkn1;
Tissue Specificity	CDK1: Isoform 2 is found in breast cancer tissues.
Note	Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.

Uniprot	P39951
Gene Id	Human(983), Mouse(12534), Rat(54237)
Gene Name	CDK1
Clone No	Clone: A17
Sequence	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Subcellular Location	Nucleus . Cytoplasm . Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Cytoplasmic during the interphase. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin B1. Accumulates in mitochondria in G2-arrested cells upon DNA- damage. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle (By similarity). .

Concentration	Adding 1 ml of PBS buffer will yield a concentration of 100 ug/ml.
Form	Lyophilized
Purification	Ascites
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 1-2ug/ml, Human, chicken, mouse, By Heat <br>Immunohistochemistry (Frozen Section), 1-2ug/ml, Human, chicken, mouse, -<br>Weste blot, 0.5-1ug/ml, Human, chicken, mouse<br>

Reference	1. Draetta, G.; Piwnica-Worms, H.; Morrison, D.; Druker, B.; Roberts, T.; Beach, D. : Human CDC2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature 336: 738-744, 1988. <br /><br />2. Spurr, N. K.; Goodfellow, P. N.; Nurse, P.; Lee, M. : Assignment of the human homologue of the yeast cell cycle control gene CDC2 to chromosome 10. (Abstract) Cytogenet. Cell Genet. 46: 698, 1987. <br /><br />3. Nazarenko, S. A.; Ostroverhova, N. V.; Spurr, N. K. : Regional assignment of the human cell cycle control gene CDC2 to chromosome 10q21 by in situ hybridization. Hum. Genet. 87: 621-622, 1991.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006547-1	MA1077	-	100 ug	$370		Add to Cart

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