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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD35/CR1 Antibody Picoband®

SKU : BHA21002331

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Mfr.No.	A01022-1, A01022-1-10ug, A01022-1-Biotin, A01022-1-Cy3, A01022-1-Dylight488, A01022-1-Dylight550, A01022-1-Dylight594, A01022-1-FITC, A01022-1-HRP, A01022-1-APC, A01022-1-PE, A01022-1-iFluor647, A01022-1-carrier-free
Alternative Names	complement C3b/C4b receptor 1 (Knops blood group)
Background	Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alteate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-CD35/CR1 Antibody Picoband® catalog # A01022-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Membrane immune adherence receptor that plays a critical role in the capture and clearance of complement-opsonized pathogens by erythrocytes and monocytes/macrophages (PubMed:2963069). Mediates the binding by these cells of particles and immune complexes
Host	Rabbit
Immunogen Region	E.coli-derived human CD35/CR1 recombinant protein (Position: D109-Q957).
Isotype	Rabbit IgG
Molecular Weight	250 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Complement receptor type 1; C3b/C4b receptor; CD35; CR1; C3BR
Tissue Specificity	Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P17927
Gene Id	1378
Gene Name	CR1
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, IHC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, By Heat<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Jacobson AC, Weis JH (Sep 2008). "Comparative functional evolution of human and mouse CR1 and CR2". J. Immunol. 181 (5): 29539.<br /><br />2. Khera R, Das N (February 2009). "Complement Receptor 1: Disease associations and therapeutic implications". Molecular Immunology. 46 (5): 761772. <br /><br />3. Moulds JM, Nickells MW, Moulds JJ, Brown MC, Atkinson JP (May 1991). "The C3b/C4b receptor is recognized by the Knops, McCoy, Swain-langley, and York blood group antisera". J. Exp. Med. 173 (5): 115963.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002331-1	A01022-1	-	100 ug	$370		Add to Cart
BHA21002331-2	A01022-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21002331-3	A01022-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002331-4	A01022-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002331-5	A01022-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002331-6	A01022-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002331-7	A01022-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002331-8	A01022-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21002331-9	A01022-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21002331-10	A01022-1-APC	APC	100 ug	$670		Add to Cart
BHA21002331-11	A01022-1-PE	PE	100 ug	$670		Add to Cart
BHA21002331-12	A01022-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002331-13	A01022-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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