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Home / Primary Antibodies / Polyclonal Antibodies

Anti-CD226 Antibody Picoband®

SKU : BHA21003244

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Mfr.No.	A01094-2, A01094-2-10ug, A01094-2-Biotin, A01094-2-Cy3, A01094-2-Dylight488, A01094-2-Dylight550, A01094-2-Dylight594, A01094-2-FITC, A01094-2-HRP, A01094-2-APC, A01094-2-PE, A01094-2-iFluor647, A01094-2-carrier-free
Alternative Names	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Background	DNAM 1, also known as CD226, is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes. This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-CD226 Antibody Picoband® catalog # A01094-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns (4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3
Host	Rabbit
Immunogen Region	E.coli-derived mouse CD226 recombinant protein (Position: E31-L333).
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform;PI3-kinase subunit beta;PI3K-beta;PI3Kbeta;PtdIns-3-kinase subunit beta;2.7.1.153;Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta;PtdIns-3-kinase subunit p110-beta;p110beta;PIK3CB;PIK3C1;
Tissue Specificity	Expressed ubiquitously.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Uniprot	Q8K4F0
Gene Id	225825
Gene Name	Cd226
Subcellular Location	Cytoplasm . Nucleus . Interaction with PIK3R2 is required for nuclear localization and export.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IHC, WB
Description	Weste blot, 0.25-0.5ug/ml, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Rat<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Bottino, C., Castriconi, R., Pende, D., Rivera, P., Nanni, M., Caemolla, B., Cantoni, C., Grassi, J., Marcenaro, S., Reymond, N., Vitale, M., Moretta, L., Lopez, M., Moretta, A. Identification of PVR (CD155) and nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. J. Exp. Med. 198: 557-567, 2003. <br /><br />2. Iguchi-Manaka, A., Kai, H., Yamashita, Y., Shibata, K., Tahara-Hanaoka, S., Honda, S., Yasui, T., Kikutani, H., Shibuya, K., Shibuya, A. Accelerated tumor growth in mice deficient in DNAM-1 receptor. J. Exp. Med. 205: 2959-2964, 2008. <br /><br />3. Liu, J., Qian, X., Chen, Z., Xu, X., Gao, F., Zhang, S., Zhang, R., Qi, J., Gao, G. F., Yan, J. Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226. J Immun. 188: 5511-5520, 2012.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003244-1	A01094-2	-	100 ug	$370		Add to Cart
BHA21003244-2	A01094-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003244-3	A01094-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003244-4	A01094-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003244-5	A01094-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003244-6	A01094-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003244-7	A01094-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003244-8	A01094-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003244-9	A01094-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003244-10	A01094-2-APC	APC	100 ug	$670		Add to Cart
BHA21003244-11	A01094-2-PE	PE	100 ug	$670		Add to Cart
BHA21003244-12	A01094-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003244-13	A01094-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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