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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Cathepsin B/CTSB Antibody Picoband®

SKU : BHA21007506

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Mfr.No.	PB9046, PB9046-10ug, PB9046-Biotin, PB9046-Cy3, PB9046-Dylight488, PB9046-Dylight550, PB9046-Dylight594, PB9046-FITC, PB9046-HRP, PB9046-APC, PB9046-PE, PB9046-iFluor647, PB9046-carrier-free
Alternative Names	Cathepsin B
Background	Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene. And this gene is mapped to chromosome 8p22. The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimer's disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimer's disease. Overexpression of cathepsin B has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. The standard product used in this kit is recombinant human Cathepsin B with the molecular mass of 37KDa.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Cathepsin B/CTSB Antibody Picoband® catalog # PB9046. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Thiol protease which is believed to participate in intracellular degradation and tuover of proteins. Has also been implicated in tumor invasion and metastasis.
Host	Rabbit
Immunogen Region	E.coli-derived human Cathepsin B recombinant protein (Position: L80-D333). Human Cathepsin B shares 83% and 84% amino acid (aa) sequences identity with mouse and rat Cathepsin B, respectively.
Isotype	Rabbit IgG
Molecular Weight	33 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cathepsin B;3.4.22.1;APP secretase;APPS;Cathepsin B1;Cathepsin B light chain;Cathepsin B heavy chain;CTSB;CPSB;
Tissue Specificity	Expressed in all cell types so far analyzed.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P07858
Gene Id	1508
Gene Name	CTSB
Sequence	Belongs to the peptidase C1 family.
Subcellular Location	Lysosome. Melanosome. Secreted, extracellular space . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human

Reference	1. Chan SJ, San Segundo B, McCormick MB, Steiner DF (October 1986). "Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs". Proc. Natl. Acad. Sci. U.S.A. 83 (20): 77215. 2. Cao L, Taggart RT, Berquin IM, Moin K, Fong D, Sloane BF (February 1994). "Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene". Gene 139 (2): 1639. 3. Wang, X.; Chan, S. J.; Eddy, R. L.; Byers, M. G.; Fukushima, Y.; Henry, W. M.; Haley, L. L.; Steiner, D. F.; Shows, T. B. : Chromosome assignment of cathepsin B (CTSB) to 8p22 and cathepsin H (CTSH) to 15q24-q25. (Abstract) Cytogenet. Cell Genet. 46: 710-711, 1987. 4. Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L (September 2006). "Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease". Neuron 51 (6): 70314.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007506-1	PB9046	-	100 ug	$370		Add to Cart
BHA21007506-2	PB9046-10ug	Sample	10 ug	$99		Add to Cart
BHA21007506-3	PB9046-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007506-4	PB9046-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007506-5	PB9046-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007506-6	PB9046-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007506-7	PB9046-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007506-8	PB9046-FITC	FITC	100 ug	$570		Add to Cart
BHA21007506-9	PB9046-HRP	HRP	100 ug	$570		Add to Cart
BHA21007506-10	PB9046-APC	APC	100 ug	$670		Add to Cart
BHA21007506-11	PB9046-PE	PE	100 ug	$670		Add to Cart
BHA21007506-12	PB9046-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007506-13	PB9046-carrier-free	carrier-free	100 ug	$370		Add to Cart

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