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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Caspase-1(P10)/CASP1 Antibody Picoband®

SKU : BHA21006861

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Mfr.No.	PA1522, PA1522-10ug, PA1522-Biotin, PA1522-Cy3, PA1522-Dylight488, PA1522-Dylight550, PA1522-Dylight594, PA1522-FITC, PA1522-HRP, PA1522-APC, PA1522-PE, PA1522-iFluor647, PA1522-carrier-free
Alternative Names	Caspase-1
Background	Caspase 1, apoptosis-related cysteine protease, is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta, IL18, and IL33 precursor proteins. Caspase 1 was purified ICE from the cytosol of the THP. human monocytic cell line and found that the active protease was made up of 2 peptides, which they called p20 and p10 based on their apparent molecular masses by SDS-PAGE. It belongs to a family of cysteine proteases known as caspases that always cleave proteins following an aspartic acid residue. The Caspase1 gene consists of 10 exons spanning at least 10.6 kb. The Caspase 1 gene is mapped to 11q23, a site frequently involved in rearrangement in human cancers, including a number of leukemias and lymphomas, by Southe DNA blot analysis of rodent-human hybrids and by in situ hybridization to normal human metaphase chromosomes. Caspase 1 has been shown to induce cell necrosis or pyroptosis and may function in various developmental stages.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-Caspase-1 (P10)/CASP1 Antibody catalog # PA1522. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding prote
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-1(P10).
Isotype	Rabbit IgG
Molecular Weight	45 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Caspase-1;CASP-1;3.4.22.36;Interleukin-1 beta convertase;IL-1BC;Interleukin-1 beta-converting enzyme;ICE;IL-1 beta-converting enzyme;p45;Caspase-1 subunit p20;Caspase-1 subunit p10;CASP1;IL1BC, IL1BCE;
Tissue Specificity	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P29466
Gene Name	CASP1
Sequence	Belongs to the peptidase C14A family.
Subcellular Location	Cytoplasm.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Cerretti, D. P., Hollingsworth, L. T., Kozlosky, C. J., Valentine, M. B., Shapiro, D. N., Morris, S. W., Nelson, N.Molecular characterization of the gene for human interleukin-1-beta converting enzyme (IL1BC).Genomics 20: 468-473, 1994.<br /><br />2. Thoberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., Elliston, K. O., Ayala, J. M., Casano, F. J., Chin, J., Ding, G. J.-F., Egger, L. A., Gaffney, E. P., Limjuco, G., Palyha, O. C., Raju, S. M., Rolando, A. M., Salley, J. P., Yamin, T.-T., Lee, T. D., Shively, J. E., MacCross, M., Mumford, R. A., Schmidt, J. A., Tocci, M. J.A novel heterodimeric cysteine protease is required for interleukin-1-beta processing in monocytes.Nature 356: 768-774, 1992.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006861-1	PA1522	-	100 ug	$370		Add to Cart
BHA21006861-2	PA1522-10ug	Sample	10 ug	$99		Add to Cart
BHA21006861-3	PA1522-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006861-4	PA1522-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006861-5	PA1522-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006861-6	PA1522-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006861-7	PA1522-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006861-8	PA1522-FITC	FITC	100 ug	$570		Add to Cart
BHA21006861-9	PA1522-HRP	HRP	100 ug	$570		Add to Cart
BHA21006861-10	PA1522-APC	APC	100 ug	$670		Add to Cart
BHA21006861-11	PA1522-PE	PE	100 ug	$670		Add to Cart
BHA21006861-12	PA1522-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006861-13	PA1522-carrier-free	carrier-free	100 ug	$370		Add to Cart

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