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Home / Primary Antibodies / Polyclonal Antibodies

Anti-C-C chemokine receptor type 4 CCR4 Antibody Picoband®

SKU : BHA21006857

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Mfr.No.	PA1517, PA1517-10ug, PA1517-Biotin, PA1517-Cy3, PA1517-Dylight488, PA1517-Dylight550, PA1517-Dylight594, PA1517-FITC, PA1517-HRP, PA1517-APC, PA1517-PE, PA1517-iFluor647, PA1517-carrier-free
Alternative Names	C-C chemokine receptor type 4
Background	CCR4,C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene. CCR4 has also recently been designated CD194 (cluster of differentiation 194). The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines. The CCR4 gene is mapped to chromosome 3. Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-C-C chemokine receptor type 4 CCR4 Antibody catalog # PA1517. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G (i) proteins which activate a phosphatidylinositol- calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of mouse CCR4, identical to the related rat sequence.
Isotype	Rabbit IgG
Molecular Weight	41 kDa
Reactivity	Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	C-C chemokine receptor type 4;C-C CKR-4;CC-CKR-4;CCR-4;CCR4;CD194;Ccr4;Cmkbr4;
Tissue Specificity	Expressed in the thymus, macrophages and T- and B-cells.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P51680
Gene Name	CCR4
Sequence	Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Subcellular Location	Cell membrane; Multi-pass membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse, Rat <br>

Reference	1. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., Yoshie, O.The T cell-ed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.J. Biol. Chem. 272: 15036-15042, 1997.<br /><br />2. Imai, T., Chantry, D., Raport, C. J., Woods, C. L., Nishimura, M., Godiska, R., Yoshie, O., Gray, P. W.Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.J. Biol. Chem. 273: 1764-1768, 1998.<br /><br />3. Oo, Y. H., Weston, C. J., Lalor, P. F., Curbishley, S. M., Withers, D. R., Reynolds, G. M., Shetty, S., Harki, J., Shaw, J. C., Eksteen, B., Hubscher, S. G., Walker, L. S. K., Adams, D. H.Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.J. Immun. 184: 2886-2898, 2010.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006857-1	PA1517	-	100 ug	$370		Add to Cart
BHA21006857-2	PA1517-10ug	Sample	10 ug	$99		Add to Cart
BHA21006857-3	PA1517-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006857-4	PA1517-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006857-5	PA1517-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006857-6	PA1517-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006857-7	PA1517-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006857-8	PA1517-FITC	FITC	100 ug	$570		Add to Cart
BHA21006857-9	PA1517-HRP	HRP	100 ug	$570		Add to Cart
BHA21006857-10	PA1517-APC	APC	100 ug	$670		Add to Cart
BHA21006857-11	PA1517-PE	PE	100 ug	$670		Add to Cart
BHA21006857-12	PA1517-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006857-13	PA1517-carrier-free	carrier-free	100 ug	$370		Add to Cart

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