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Home / Primary Antibodies / Polyclonal Antibodies

Anti-BAG2 Antibody Picoband®

SKU : BHA21007305

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Mfr.No.	PA2099, PA2099-10ug, PA2099-Biotin, PA2099-Cy3, PA2099-Dylight488, PA2099-Dylight550, PA2099-Dylight594, PA2099-FITC, PA2099-HRP, PA2099-APC, PA2099-PE, PA2099-iFluor647, PA2099-carrier-free
Alternative Names	BAG family molecular chaperone regulator 2
Background	BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-BAG2 Antibody catalog # PA2099. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human BAG2, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	140-150 kDa
Reactivity	Rat, Mouse, Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	BAG family molecular chaperone regulator 2;BAG-2;Bcl-2-associated athanogene 2;BAG2;
Tissue Specificity	Expressed in the brain, heart, liver, skeletal muscle, pancreas and placenta. Isoform 1 is predominant in the brain and spinal cord. Isoform 4 is more abundant in the cerebellum. In the brain, broadly expressed in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O95816
Gene Name	BAG2
Subcellular Location	Cytoplasm .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. Takayama S, Xie Z, Reed JC (Feb 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J Biol Chem 274 (2): 7816. <br /><br />"Entrez Gene: BAG2 BCL2-associated athanogene 2"<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007305-1	PA2099	-	100 ug	$370		Add to Cart
BHA21007305-2	PA2099-10ug	Sample	10 ug	$99		Add to Cart
BHA21007305-3	PA2099-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007305-4	PA2099-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007305-5	PA2099-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007305-6	PA2099-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007305-7	PA2099-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007305-8	PA2099-FITC	FITC	100 ug	$570		Add to Cart
BHA21007305-9	PA2099-HRP	HRP	100 ug	$570		Add to Cart
BHA21007305-10	PA2099-APC	APC	100 ug	$670		Add to Cart
BHA21007305-11	PA2099-PE	PE	100 ug	$670		Add to Cart
BHA21007305-12	PA2099-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007305-13	PA2099-carrier-free	carrier-free	100 ug	$370		Add to Cart

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