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Home / Primary Antibodies / Polyclonal Antibodies

Anti-BAFF/TNFSF13B Antibody Picoband®

SKU : BHA21006874

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Mfr.No.	PA1541, PA1541-10ug, PA1541-Biotin, PA1541-Cy3, PA1541-Dylight488, PA1541-Dylight550, PA1541-Dylight594, PA1541-FITC, PA1541-HRP, PA1541-APC, PA1541-PE, PA1541-iFluor647, PA1541-carrier-free
Alternative Names	Tumor necrosis factor ligand superfamily member 13B
Background	BAFF was regularly detected by enzyme-linked immunosorbent assay in brain tissue lysates and in normal spinal fluid, and in astrocytes by double fluorescence microscopy. BAFF was localized in astrocytes close to BAFF-R-expressing immune cells. BAFF receptors were strongly expressed in situ in primary central nervous system (CNS) lymphomas. The TNF superfamily member B cell-activating factor (BAFF) plays an important role in humoral immunity and in autoimmune diseases, including RA.Local BAFF gene targeting inhibited proinflammatory cytokine expression, suppressed generation of plasma cells and Th17 cells, and markedly ameliorated joint pathology. The B cell activating factor BAFF (BlyS/TALL-1/zTNF4) is a tumor necrosis factor (TNF)-related ligand that promotes B cell survival and binds to three receptors (BCMA, TACI, and the recently described BAFF-R). Human BAFF was mapped to chromosome 13q32-34.4. The standard used in this kit is recombinant soluble human BAFF (A134-L295) with the molecular mass of 19.6KDa.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-BAFF/TNFSF13B Antibody catalog # PA1541. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A thir
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human BAFF, different from the related rat and mouse sequences by three amino acids.
Isotype	Rabbit IgG
Molecular Weight	17 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Tumor necrosis factor ligand superfamily member 13B;B lymphocyte stimulator;BLyS;B-cell-activating factor;BAFF;Dendritic cell-derived TNF-like molecule;TNF- and APOL-related leukocyte expressed ligand 1;TALL-1;CD257;Tumor necrosis factor ligand superfamily member 13b, membrane form;Tumor necrosis factor ligand superfamily member 13b, soluble form;TNFSF13B;BAFF, BLYS, TALL1, TNFSF20, ZTNF4;UNQ401/PRO738;
Tissue Specificity	Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T- cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9Y275
Gene Name	TNFSF13B
Sequence	Belongs to the tumor necrosis factor family.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br>

Reference	1. Krumbholz, M., Theil, D., Derfuss, T., Rosenwald, A., Schrader, F., Monoranu, C.-M., Kalled, S. L., Hess, D. M., Serafini, B., Aloisi, F., Wekerle, H., Hohlfeld, R., Meinl, E. BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. J. Exp. Med. 201: 195-200, 2005.<br /><br />2. Lam, Q. L. K., Ko, O. K. H., Zheng, B.-J., Lu, L. Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis. Proc. Nat. Acad. Sci. 105: 14993-14998, 2008.<br /><br />3. Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E., Scott, M. L. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293: 2111-2114, 2001.<br /><br />4. Schneider, P., MacKay, F., Steiner, V., Hofmann, K., Bodmer, J. L., Holler, N., Ambrose, C., Lawton, P., Bixler, S., Acha-Orbea, H., Valmori, D., Romero, P., Weer-Favre, C., Zubler, R. H., Browning, J. L., Tschopp, J. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J. Exp. Med. 189: 1747-1756, 1999.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006874-1	PA1541	-	100 ug	$370		Add to Cart
BHA21006874-2	PA1541-10ug	Sample	10 ug	$99		Add to Cart
BHA21006874-3	PA1541-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006874-4	PA1541-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006874-5	PA1541-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006874-6	PA1541-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006874-7	PA1541-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006874-8	PA1541-FITC	FITC	100 ug	$570		Add to Cart
BHA21006874-9	PA1541-HRP	HRP	100 ug	$570		Add to Cart
BHA21006874-10	PA1541-APC	APC	100 ug	$670		Add to Cart
BHA21006874-11	PA1541-PE	PE	100 ug	$670		Add to Cart
BHA21006874-12	PA1541-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006874-13	PA1541-carrier-free	carrier-free	100 ug	$370		Add to Cart

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