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Home / Primary Antibodies / Polyclonal Antibodies

Anti-B MyB/MYBL2 Antibody Picoband®

SKU : BHA21003294

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Mfr.No.	A02597, A02597-10ug, A02597-Biotin, A02597-Cy3, A02597-Dylight488, A02597-Dylight550, A02597-Dylight594, A02597-FITC, A02597-HRP, A02597-APC, A02597-PE, A02597-iFluor647, A02597-carrier-free
Alternative Names	ADAM metallopeptidase domain 15
Background	MYBL2 (V-MYB avian myeloblastosis viral oncogene homolog-like 2), also called MYB-RELATED GENE BMYB, is a protein that in humans is encoded by the MYBL2 gene. The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. Barletta et al. (1991) assigned the MYBL2 gene to chromosome Xq13. However, Noben-Trauth et al. (1996) demonstrated that this assignment was an error. Using mouse Mybl2 cDNA clones as probes, they assigned Mybl2 in an interspecific backcross panel to distal mouse chromosome 2. Using human cDNA probes in combination with fluorescence in situ hybridization analysis, they localized MYBL2 to chromosome 20q13.1, a region that is commonly deleted in myeloid disorders and shows high homology of synteny to mouse chromosome 2. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-B MyB/MYBL2 Antibody Picoband® catalog # A02597. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell
Host	Rabbit
Immunogen Region	E.coli-derived human B MyB/MYBL2 recombinant protein (Position: K31-R695).
Isotype	Rabbit IgG
Molecular Weight	100 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; MDC-15; Metargidin; ADAM15; MDC15
Tissue Specificity	Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4.

Uniprot	P10244
Gene Id	4605
Gene Name	MYBL2
Subcellular Location	Endomembrane system. Single-pass type I membrane protein. Adherens junction. Flagellum. Acrosome.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Barletta, C., Druck, T., LaForgia, S., Calabretta, B., Drabkin, H., Patterson, D., Croce, C. M., Huebner, K. Chromosome locations of the MYB related genes, AMYB and BMYB. Cancer Res. 51: 3821-3824, 1991.<br /><br />2. Noben-Trauth, K., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Sonoda, G., Testa, J. R., Klempnauer, K.-H. Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q13.1. Genomics 35: 610-612, 1996.<br /><br />3. Shepard, J. L., Amatruda, J. F., Ste, H. M., Subramanian, A., Finkelstein, D., Ziai, J., Finley, K. R., Pfaff, K. L., Hersey, C., Zhou, Y., Barut, B., Freedman, M., and 9 others. A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc. Nat. Acad. Sci. 102: 13194-13199, 2005.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003294-1	A02597	-	100 ug	$370		Add to Cart
BHA21003294-2	A02597-10ug	Sample	10 ug	$99		Add to Cart
BHA21003294-3	A02597-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003294-4	A02597-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003294-5	A02597-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003294-6	A02597-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003294-7	A02597-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003294-8	A02597-FITC	FITC	100 ug	$570		Add to Cart
BHA21003294-9	A02597-HRP	HRP	100 ug	$570		Add to Cart
BHA21003294-10	A02597-APC	APC	100 ug	$670		Add to Cart
BHA21003294-11	A02597-PE	PE	100 ug	$670		Add to Cart
BHA21003294-12	A02597-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003294-13	A02597-carrier-free	carrier-free	100 ug	$370		Add to Cart

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