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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ATF4 Antibody Picoband®

SKU : BHA21006871

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Mfr.No.	PA1537, PA1537-10ug, PA1537-Biotin, PA1537-Cy3, PA1537-Dylight488, PA1537-Dylight550, PA1537-Dylight594, PA1537-FITC, PA1537-HRP, PA1537-APC, PA1537-PE, PA1537-iFluor647, PA1537-carrier-free
Alternative Names	Cyclic AMP-dependent transcription factor ATF-4
Background	ATF4, Activating Transcription Factor 4, is also know as CREB2. ATF4 belongs to the large ATF/CREB family of transcription factors which bind DNA via their basic region and dimerize via their leucine zipper domain to form a variety of homo- and heterodimers to regulate gene transcription. It is identified that members of this family share significant sequence similarity within a leucine zipper DNA-binding motif and an adjacent basic region. The ATF4 gene is mapped to chromosome 22. Unlike CREB, which activates transcription from CRE-containing promoters, CREB2 functions as a specific repressor of CRE-dependent transcription. The transcriptional repressor activity resides within the C-terminal leucine zipper and basic domain region of the CREB2 protein.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ATF4 Antibody catalog # PA1537. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT(AC)(AG)-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human ATF4, identical to the related rat and mouse sequences.
Isotype	Rabbit IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Cyclic AMP-dependent transcription factor ATF-4;cAMP-dependent transcription factor ATF-4;Activating transcription factor 4;Cyclic AMP-responsive element-binding protein 2;CREB-2;cAMP-responsive element-binding protein 2;DNA-binding protein TAXREB67;Tax-responsive enhancer element-binding protein 67;TaxREB67;ATF4;CREB2, TXREB;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P18848
Gene Name	ATF4
Sequence	Belongs to the bZIP family.
Subcellular Location	Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Co- localizes with NEK6 in the centrosome. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat, Mouse<br>

Reference	1. De Angelis, R., Iezzi, S., Bruno, T., Corbi, N., Di Padova, M., Floridi, A., Fanciulli, M., Passananti, C.Functional interaction of the subunit 3 of RNA polymerase II (RPB3) with transcription factor-4 (ATF4).FEBS Lett. 547: 15-19, 2003.<br /><br />2. Hai, T., Liu, F., Coukos, W. J., Green, M. R.Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.Genes Dev. 3: 2083-2090, 1989.<br /><br />3. Karpinski, B. A., Morle, G. D., Huggenvik, J., Uhler, M. D., Leiden, J. M.Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.Proc. Nat. Acad. Sci. 89: 4820-4824, 1992.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006871-1	PA1537	-	100 ug	$370		Add to Cart
BHA21006871-2	PA1537-10ug	Sample	10 ug	$99		Add to Cart
BHA21006871-3	PA1537-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006871-4	PA1537-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006871-5	PA1537-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006871-6	PA1537-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006871-7	PA1537-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006871-8	PA1537-FITC	FITC	100 ug	$570		Add to Cart
BHA21006871-9	PA1537-HRP	HRP	100 ug	$570		Add to Cart
BHA21006871-10	PA1537-APC	APC	100 ug	$670		Add to Cart
BHA21006871-11	PA1537-PE	PE	100 ug	$670		Add to Cart
BHA21006871-12	PA1537-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006871-13	PA1537-carrier-free	carrier-free	100 ug	$370		Add to Cart

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