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Home / Primary Antibodies / Polyclonal Antibodies

Anti-Aquaporin 5/AQP5 Antibody Picoband®

SKU : BHA21001884

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Mfr.No.	A03085, A03085-10ug, A03085-Biotin, A03085-Cy3, A03085-Dylight488, A03085-Dylight550, A03085-Dylight594, A03085-FITC, A03085-HRP, A03085-APC, A03085-PE, A03085-iFluor647, A03085-carrier-free
Alternative Names	aquaporin 5
Background	Aquaporin 5, also known as AQP5, is a water channel protein. The aquaporins (AQPs) are a family of more than 10 homologous water transporting proteins expressed in many mammalian epithelia and endothelia. At least five AQPs are expressed in the eye: AQP0 (MIP) in lens fiber, AQP1 in coea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP4 in ciliary epithelium and retinal Müller cells, and AQP5 in coeal and lacrimal gland epithelia. Among the seven human aquaporins cloned to date (AQPs 0-6), genes encoding the four most closely related aquaporins (AQP0, AQP2, AQP5, and AQP6) have been mapped to chromosome band 12q13, suggesting an aquaporin family gene cluster at this locus. Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-Aquaporin 5/AQP5 Antibody Picoband® catalog # A03085. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity (PubMed:16571723). Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 5, which shares 71.7% and 73% amino acid (aa) sequence identity with mouse and rat Aquaporin 5, respectively.
Isotype	Rabbit IgG
Molecular Weight	28 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Aquaporin-5; AQP-5; AQP5
Tissue Specificity	Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P55064
Gene Id	362
Gene Name	AQP5
Subcellular Location	Apical cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml<br>

Reference	1. Verkman AS (2003). "Role of aquaporin water channels in eye function.". Exp. Eye Res. 76 (2): 13743.<br /><br />2. Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13.". Genomics 43 (3): 3879.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21001884-1	A03085	100 ug	-	$370		Add to Cart
BHA21001884-2	A03085-10ug	10 ug	Sample	$99		Add to Cart
BHA21001884-3	A03085-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21001884-4	A03085-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21001884-5	A03085-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21001884-6	A03085-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21001884-7	A03085-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21001884-8	A03085-FITC	100 ug	FITC	$570		Add to Cart
BHA21001884-9	A03085-HRP	100 ug	HRP	$570		Add to Cart
BHA21001884-10	A03085-APC	100 ug	APC	$670		Add to Cart
BHA21001884-11	A03085-PE	100 ug	PE	$670		Add to Cart
BHA21001884-12	A03085-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21001884-13	A03085-carrier-free	100 ug	carrier-free	$370		Add to Cart

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