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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ABCB6 Antibody Picoband®

SKU : BHA21007009

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Mfr.No.	PA1723, PA1723-10ug, PA1723-Biotin, PA1723-Cy3, PA1723-Dylight488, PA1723-Dylight550, PA1723-Dylight594, PA1723-FITC, PA1723-HRP, PA1723-APC, PA1723-PE, PA1723-iFluor647, PA1723-carrier-free
Alternative Names	ATP-binding cassette sub-family B member 6, mitochondrial
Background	ABCB6, ATP-binding cassette sub-family B member 6, mitochondrialis a protein that in humans is encoded by the ABCB6 gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ABCB6 Antibody catalog # PA1723. Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB6.
Isotype	Rabbit IgG
Molecular Weight	94 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	ATP-binding cassette sub-family B member 6, mitochondrial;Mitochondrial ABC transporter 3;Mt-ABC transporter 3;P-glycoprotein-related protein;Ubiquitously-expressed mammalian ABC half transporter;ABCB6;MTABC3, PRP, UMAT;
Tissue Specificity	Widely expressed. High expression is detected in the retinal epithelium. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9NP58
Gene Name	ABCB6
Sequence	Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Subcellular Location	Cell membrane. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus. Endosome . localized to the endosome- like compartement and dendrite tips.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, ICC, WB
Description	Immunocytochemistry , 0.5-1ug/ml, Human, -<br>Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Helias, V., Saison, C., Ballif, B. A., Peyrard, T., Takahashi, J., Takahashi, H., Tanaka, M., Deybach, J.-C., Puy, H., Le Gall, M., Sureau, C., Pham, B.-N., Le Pennec, P.-Y., Tani, Y., Cartron, J.-P., Aaud, L.ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis.Nature Genet. 44: 170-173, 2012.<br /><br />2. Krishnamurthy, P. C., Du, G., Fukuda, Y., Sun, D., Sampath, J., Mercer, K. E., Wang, J., Sosa-Pineda, B., Murti, K. G., Schuetz, J. D.Identification of a mammalian mitochondrial porphyrin transporter.Nature 443: 586-589, 2006.<br /><br />3. Wang, L., He, F., Bu, J., Liu, X., Du, W., Dong, J., Cooney, J. D., Dubey, S. K., Shi, Y., Gong, B., Li, J., McBride, P. E., and 11 others.ABCB6 mutations cause ocular coloboma.Am. J. Hum. Genet. 90: 40-48, 2012.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007009-1	PA1723	-	100 ug	$370		Add to Cart
BHA21007009-2	PA1723-10ug	Sample	10 ug	$99		Add to Cart
BHA21007009-3	PA1723-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007009-4	PA1723-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007009-5	PA1723-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007009-6	PA1723-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007009-7	PA1723-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007009-8	PA1723-FITC	FITC	100 ug	$570		Add to Cart
BHA21007009-9	PA1723-HRP	HRP	100 ug	$570		Add to Cart
BHA21007009-10	PA1723-APC	APC	100 ug	$670		Add to Cart
BHA21007009-11	PA1723-PE	PE	100 ug	$670		Add to Cart
BHA21007009-12	PA1723-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007009-13	PA1723-carrier-free	carrier-free	100 ug	$370		Add to Cart

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