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Home / Primary Antibodies / Polyclonal Antibodies

Annexin A1 Antibody (pTyr207) - SPC-916

BHA11911304
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+1 866.986.9598
Email
[email protected]
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Swissprot P04083
Accession Number NP_000691
Gene Id 301
Target Annexin A1 (pTyr207)
Research Area Cell adhesion, Cell Signaling, Annexins, Lipid Signaling, Cytoskeleton
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Detected in resting neutrophils, peripheral blood T-cells, placenta, liver.
Scientific Background Annexin A2 (ANXA2), also known as Annexin II and Lipocortin II (LPC2), is a 38.6 kDa member of the Annexin family of proteins. The Annexins are a family of Calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexin's have a molecular weight of approximately 35?40 kDa and consist of a unique amino terminal domain followed by a homologous C-terminal core domain containing the calcium-dependent phospholipid-binding sites. The C-terminal domain is comprised of four 60?70 amino acid (aa) repeats, known as annexin repeats or an endonexin fold (Annexin A6 contains 8 annexin repeats). The four annexin repeats form a highly alpha -helical, tightly packed disc known as the annexin domain, which binds to phospholipids in the membrane in a calcium-dependent manner. Members of the annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. Annexin A2 was identified as an inhibitor of phospholipase A2 activity. Annexin A2 also functions as an autocrine factor to enhance osteoclast formation and bone resorption and is a major cellular substrate of the tyrosine kinase encoded by the SRC oncogene. Human Annexin A2 shares 97% identity with mouse and rat Annexin A2.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 38.714 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11911304-1 SPC-916D Unconjugated 100 ul $331
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BHA11911304-2 SPC-916D-A390 ATTO 390 100 ul $385
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BHA11911304-3 SPC-916D-A488 ATTO 488 100 ul $384
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BHA11911304-4 SPC-916D-A594 ATTO 594 100 ul $384
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BHA11911304-5 SPC-916D-BI Biotin 100 ul $380
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BHA11911304-6 SPC-916D-FITC FITC 100 ul $375
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