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Home / Antibodies

Androgen Receptor Antibody (F42684)

SKU : BHA17100533

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Mfr.No.	F42684, F42684-0.08ML, F42684-0.4ML
Antigen	AR
Clonality	Polyclonal
Description	The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. (provided by RefSeq).
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 282-309 from the human protein was used as the immunogen for this AR antibody.
Isotype	Ig
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P10275

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the AR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Dilution	Western blot: 1:1000

Product Manual	Data Sheet

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17100533-1	F42684-0.08ML	0.08ml	$165		Add to Cart
BHA17100533-2	F42684-0.4ML	0.4ml	$379		Add to Cart

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