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Home / Primary Antibodies

AMACR / p504S Antibody (Prostate Cancer Marker) (V8435SAF)

SKU : BHA17127491

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NSJ Bioreagents

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Mfr.No.	V8435SAF-100UG
Clonality	Recombinant Rabbit Monoclonal
Description	This antibody recognizes a protein of 42kDa, which is identified as AMACR, also known as p504S. It is an enzyme that is involved in bile acid biosynthesis and -oxidation of branched-chain fatty acids. AMACR is essential in lipid metabolism. It is expressed in cells of premalignant high-grade prostatic intraepithelial neoplasia (HGPIN) and prostate adenocarcinoma. The majority of the carcinoma cells show a distinct granular cytoplasmic staining reaction. AMACR is present at low or undetectable levels in glandular epithelial cells of normal prostate and benign prostatic hyperplasia. A spotty granular cytoplasmic staining is seen in a few cells of the benign glands. AMACR is expressed in normal liver (hepatocytes), kidney (tubular epithelial cells) and gall bladder (epithelial cells). Expression has also been found in lung (bronchial epithelial cells) and colon (colonic surface epithelium). AMACR expression can also be found in hepatocellular carcinoma and kidney carcinoma. Past studies have also shown that AMACR is expressed in various colon carcinomas (well, moderately and poorly differentiated) and over expressed in prostate carcinoma.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Rabbit
Immunogen Region	Recombinant full-length human AMACR protein was used as the immunogen for the recombinant AMACR antibody.
Isotype	Rabbit IgG
Species Reactivity	Human
Note	Optimal dilution of the recombinant AMACR antibody should be determined by the researcher.

Uniprot	Q9UHK6

Format	Purified
Purity	Protein A affinity chromatography
Storage	Store the recombinant AMACR antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	WB, IHC-P
Description	Weste blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/recombinant-amacr-antibody-amacr-3931r-v8435" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127491	V8435SAF-100UG	100 ug	$499		Add to Cart

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