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Home / Primary Antibodies

ALK Antibody / Anaplastic Lymphoma Kinase (V8812SAF)

SKU : BHA17122871

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NSJ Bioreagents

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Mfr.No.	V8812SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining patte. This MAb also reacts with blood vessels that serves as an inteal positive control.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A portion of amino acids 220-335 was used as the immunogen for the Anaplastic Lymphoma Kinase antibody.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human
Note	Optimal dilution of the Anaplastic Lymphoma Kinase antibody should be determined by the researcher.

Uniprot	Q9UM73

Format	Purified
Purity	Protein A/G affinity
Storage	Aliquot the Anaplastic Lymphoma Kinase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot: 1-2ug/ml

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17122871	V8812SAF-100UG	100ug	$499		Add to Cart

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