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Home / Primary Antibodies

ALDOB Antibody

SKU : BHA10558410

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA698350
Alternative Names	ALDB; ALDOB; ALFB; EC 4.1.2.13; Fructose-bisphosphate aldolase B
Categories	Primary Antibodies
Clonality	polyclonal
Description	Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.Paolella G., Nucleic Acids Res. 12:7401-7410(1984).Sakakibara M., Nucleic Acids Res. 13:5055-5069(1985).Rottmann W.H., Proc. Natl. Acad. Sci. U.S.A. 81:2738-2742(1984).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ALDOB.
Involvement In Disease	Hereditary fructose intolerance (HFI)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. Paolella G., Nucleic Acids Res. 12:7401-7410(1984). Sakakibara M., Nucleic Acids Res. 13:5055-5069(1985). Rottmann W.H., Proc. Natl. Acad. Sci. U.S.A. 81:2738-2742(1984).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ALDOB protein.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite

Uniprot	P05062
Gene Id	229
Database Links	HGNC:417 OMIM:229600 KEGG:hsa:229 STRING:9606.ENSP00000363988 UniGene:Hs.530274
Protein Families	Class I fructose-bisphosphate aldolase family
Weight	39,473 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558410	CSB-PA698350	100ul	$297		Add to Cart

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