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Home / Antibodies

ALDH2 Antibody (R31184)

SKU : BHA17104653

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Mfr.No.	R31184
Clonality	Polyclonal
Description	Aldehyde Dehydrogenase 2 is a human gene. The enzyme encoded by this gene belongs to the ALDH family of enzymes that catalyze the chemical transformation from acetaldehyde to acetic acid. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Hsu et al.(1985) assigned the ALDH2 locus to chromosome 12 by means of a cDNA probe and Southe blot analysis of somatic cell hybrids. Using an unbiased proteomic search, Chen et al.(2008) identified mitochondrial ALDH2 as an enzyme whose activation correlated with reduced ischemic heart damage in rodent models. A high-throughput screen identified a small molecule activator of ALDH2, which they called Alda-1, that, when administered to rats before an ischemic event, reduced infarct size by 60%, most likely through its inhibitory effect on the formation of cytotoxic aldehydes.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the N-terminus of human Aldehyde Dehydrogenase 2 (SAAATQAVPAPNQQPE) was used as the immunogen for this ALDH2 antibody.
Isotype	IgG
Predicted Reactivity	Human, Rat
Reactivity	Human, Rat
Recombinant	No

Uniprot	P05091

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the ALDH2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Weste blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104653	R31184	100 ug	$419		Add to Cart

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