PKB alpha also knows as V-AKT murine thymoma vial oncogene homolog 1(ATK1). AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and is abrogated by mutations in the pleckstrin homology domain of AKT1. The gene is mapped to chromosome 14q32.3. The protein is critical for ischemic and VEGF-mediated angiogenesis. It regulates pathological angiogenesis, vascular maturation and permeability in vivo.
Formulation
0.5mg/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1XPBS
Host
Mouse
Immunogen Region
Amino acids 461-477 of human PKB alpha/Akt1 were used as the immunogen for this Akt1 antibody.
Isotype
IgG1
Predicted Reactivity
Human, mouse, rat, chicken
Reactivity
Human, Mouse, Rat, Chicken
Recombinant
No
Gene Id
207
Clone No
PKB-175
Format
Ascites
Purification
Ascites
Storage
After reconstitution, the Akt1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.