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Home / Primary Antibodies / Polyclonal Antibodies

AKT1 Antibody (pTyr315) - SPC-911

BHA11911214
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
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Swissprot P31749
Accession Number NP_005154
Gene Id 207
Target AKT1 (pTyr315)
Research Area Cell Signaling, Protein Phosphorylation, Serine / Threonine Kinases, PKB / AKT, Cancer, Apoptosis, Metabolism, Metabolism processes
Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal
Dilutions WB (1:250); optimal dilutions for assays should be determined by the user.
Purification Peptide Affinity Purified
Purity Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
Scientific Background AKT1 is a protein-serine/threonine kinase which is inactive in the cytoplasm. When PI3K is activated by extracellular growth factors, AKT1 is recruited to the cell membrane and phosphorylated to become active. This leads to the induction of survival, proliferation, angiogenesis and metabolism pathways. AKT1 is also involved in cell-cycle progression via its inhibitory phosphorylation of cyclin-dependent kinases and activatory phosphorylation of mTOR. Upregulation of the PI3K/AKT pathways has been implicated in a variety of cancers.
Shipping Temperature Blue Ice or 4°C
Specificity Detects 55.686 kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.025% Thimerosal *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, WB
Description WB ; AM
Dilution WB (1:250); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11911214-1 SPC-911D Unconjugated 100 ul $331
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BHA11911214-2 SPC-911D-A390 ATTO 390 100 ul $385
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BHA11911214-3 SPC-911D-A488 ATTO 488 100 ul $384
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BHA11911214-4 SPC-911D-A594 ATTO 594 100 ul $384
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BHA11911214-5 SPC-911D-BI Biotin 100 ul $380
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BHA11911214-6 SPC-911D-FITC FITC 100 ul $375
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