AKT1 / 2 / 3 (pY315 / 316 / 312) Antibody

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Mfr.No.	abx000325
Conjugate	Unconjugated
Gene Symbol	AKT1, AKT2, AKT3
Host	Rabbit
Form	Liquid
Immunogen	Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y315/316/312 of human AKT1/AKT2/AKT3.
Purification	Affinity purified.
Isotype	IgG
Tested Application	WB, IHC, IF/ICC
Uniprotkb	P31749 (UniProt, ExPASy) P31751 (UniProt, ExPASy) Q9Y243 (UniProt, ExPASy)
Gene Id	207/208/10000
Availability	Shipped within 5-10 working days.
Concentration	> 1 mg/ml
Target	AKT1/2/3 (pY315/316/312)
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Reactivity	Human, Mouse, Rat
Molecular Weight	Calculated MW: 48 kDa, 55 kDa, 51 kDa, 54 kDa , Observed MW: 56 kDa
Note	This product is for research use only.
Clonality	polyclonal
Buffer	PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Recommended Dilution	WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Description	AKT1/2/3 (pY315/316/312) Antibody is a Rabbit Polyclonal antibody against AKT1/2/3 (pY315/316/312). The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

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SKU	Supplier No.	Size	Your price
BHA144143596	abx000325	20 ul	$174	Add to Cart
BHA144143596	abx000325	50 ul	$333.50	Add to Cart
BHA144143596	abx000325	100 ul	$493	Add to Cart
BHA144143596	abx000325	200 ul	$710.50	Add to Cart

AKT1 / 2 / 3 (pY315 / 316 / 312) Antibody

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