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Home / Primary Antibodies

AIFM1 Antibody / AIF / Apoptosis-Inducing Factor (F54034)

SKU : BHA17119930

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NSJ Bioreagents

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Mfr.No.	F54034-0.1ML
Clonality	Monoclonal (mouse origin)
Description	Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. (UniProt)
Formulation	Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Host	Mouse
Immunogen Region	A human recombinant partial protein was used as the immunogen for this AIF antibody.
Isotype	Mouse IgG2a
Species Reactivity	Human
Note	The stated application concentrations are suggested starting points. Titration of the AIF antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Uniprot	O95831

Format	Purified
Purity	Protein G affinity
Storage	Store the AIF antibody at -20oC.

Applications	WB, ICC/IF
Description	Weste blot: 1:1000,ICC/Immunofluorescence: 1:200

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119930	F54034-0.1ML	0.1 ml	$379		Add to Cart

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