AHA1; activator of heat shock 90kDa protein ATPase homolog 1;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Cochaperone that stimulates HSP90 ATPase activity By similarity. May affect a step in the endoplasmic reticulum to Golgi trafficking.Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).Heilig R., Nature 421:601-607(2003).Zhang Q.-H., Genome Res. 10:1546-1560(2000).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human AHSA1.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Cochaperone that stimulates HSP90 ATPase activity By similarity. May affect a step in the endoplasmic reticulum to Golgi trafficking.
Hu R.-M., Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000). Heilig R., Nature 421:601-607(2003). Zhang Q.-H., Genome Res. 10:1546-1560(2000).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total AHSA1 protein.
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins
Protein Families
AHA1 family
Tissue Specificity
Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
Weight
32,340 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.