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Home / Antibodies

ADRBK1 (Ab-86) Antibody

SKU : BHA10559160

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA122053
Alternative Names	ADRBK1; adrenergic; beta; receptor kinase 1; ARBK1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.Benovic J.L., FEBS Lett. 283:122-126(1991).Chuang T.T., J. Biol. Chem. 267:6886-6892(1992).Penn R.B., J. Biol. Chem. 269:14924-14930(1994).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human ADRBK1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Benovic J.L., FEBS Lett. 283:122-126(1991). Chuang T.T., J. Biol. Chem. 267:6886-6892(1992). Penn R.B., J. Biol. Chem. 269:14924-14930(1994).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ADRBK1protein.
Subcellular Location	Cytoplasm, Cell membrane

Uniprot	P25098
Gene Id	156
Database Links	HGNC:289 OMIM:109635 KEGG:hsa:156 STRING:9606.ENSP00000312262 UniGene:Hs.83636
Function	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
Pathway	Chemokine signaling pathway Hedgehog signaling pathway Endocytosis Glutamatergic synapse
Protein Families	Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
Tissue Specificity	Expressed in peripheral blood leukocytes.
Weight	80kDa

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559160	CSB-PA122053	100ul	$297		Add to Cart

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