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Home / Primary Antibodies

ADRA2B Antibody

SKU : BHA10557816

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA585658
Alternative Names	ADA2B; ADRA2L1; ADRA2RL1; ADRARL1; ALPHA2BAR
Categories	Primary Antibodies
Clonality	polyclonal
Description	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.Lomasney J.W., Proc. Natl. Acad. Sci. U.S.A. 87:5094-5098(1990).Weinshank R.L., Mol. Pharmacol. 38:681-688(1990).Small K.M., J. Biol. Chem. 276:4917-4922(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human Adrenergic Receptor alpha-2B.
Involvement In Disease	Epilepsy, familial adult myoclonic, 2 (FAME2)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. Lomasney J.W., Proc. Natl. Acad. Sci. U.S.A. 87:5094-5098(1990). Weinshank R.L., Mol. Pharmacol. 38:681-688(1990). Small K.M., J. Biol. Chem. 276:4917-4922(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Adrenergic Receptor alpha-2B protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein

Uniprot	P18089
Gene Id	151
Database Links	HGNC:282 OMIM:104260 KEGG:hsa:151 STRING:9606.ENSP00000387281 UniGene:Hs.247686
Function	Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol.
Pathway	cGMP-PKG signaling pathway
Protein Families	G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRA2B sub-subfamily
Weight	49,566 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, IF

Description

ELISA ; IF, IF ; ELISA

Dilution

IF	1:100-1:500

Tested Application

ELISA,IF;IF:1:100-1:500

Datasheet
ELISA Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557816	CSB-PA585658	100ul	$297		Add to Cart

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