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Home / Primary Antibodies

ADIPOQ Antibody

SKU : BHA10557620

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA828343
Alternative Names	ACDC; ADPN; APM1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-a by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.Yamauchi T., Kamon J., Waki H. Kadowaki T.Nat. Med. 7:941-946(2001)Richards A.A., Stephens T., Charlton H.K. Mol. Endocrinol. 20:1673-1687(2006)
Host	Rabbit
Immunogen	Peptide sequence around aa.235~239(T-G-F-L-L) derived from Human Adiponectin., Peptide sequence around aa.235~239(T-G-F-L-L) derived from Human Adiponectin.
Involvement In Disease	Adiponectin deficiency (ADPND); Diabetes mellitus, non-insulin-dependent (NIDDM)
Raised In	Rabbit
Reactivity	Human, Mouse, Mouse, Rat
Regulatory	RUO
Relevance	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-a by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. Yamauchi T., Kamon J., Waki H. Kadowaki T.Nat. Med. 7:941-946(2001) Richards A.A., Stephens T., Charlton H.K. Mol. Endocrinol. 20:1673-1687(2006)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total Adiponectin protein.
Subcellular Location	Secreted

Uniprot	Q15848
Gene Id	9370, 9370
Database Links	HGNC:13633 OMIM:125853 KEGG:hsa:9370 STRING:9606.ENSP00000320709 UniGene:Hs.80485
Function	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Pathway	PPAR signaling pathway Adipocytokine signaling pathway AMPK signaling, PPAR signaling pathway Adipocytokine signaling pathway AMPK signaling
Tissue Specificity	Synthesized exclusively by adipocytes and secreted into plasma.
Weight	26,414 Da

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol., Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557620	CSB-PA828343	100ul	$297		Add to Cart

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