Chaperone activity of bc1 complex-like; mitochondrial [Precursor]; Chaperone-ABC1-like; aarF domain-containing protein kinase 3; CABC1
Categories
Primary Antibodies
Clonality
polyclonal
Description
Putative protein kinase involved in the biosynthesis of coenzyme Q since it is able to rescue partially coenzyme Q6 biosynthesis of yeast COQ8 mutants. May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.Iiizumi M., Cancer Res. 62:1246-1250(2002).Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).Gregory S.G., Nature 441:315-321(2006).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ADCK3.
Involvement In Disease
Coenzyme Q10 deficiency, primary, 4 (COQ10D4)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Putative protein kinase involved in the biosynthesis of coenzyme Q since it is able to rescue partially coenzyme Q6 biosynthesis of yeast COQ8 mutants. May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
Iiizumi M., Cancer Res. 62:1246-1250(2002). Wan D., Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004). Gregory S.G., Nature 441:315-321(2006).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ADCK3 protein.
Subcellular Location
Mitochondrion, Membrane, Single-pass membrane protein
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration
Protein Families
Protein kinase superfamily, ADCK protein kinase family
Tissue Specificity
Widely expressed, with highest levels in adrenal gland, heart, pancreas, nasal mucosa, stomach, uterus and skeletal muscle.
Weight
42,537 Da
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.