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Home / Primary Antibodies

ADAMTS18 Antibody

SKU : BHA10558197

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA999160
Alternative Names	A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM-TS 18; ADAM-TS18; ADAMTS-18EC=3.4.24.-;
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.Cal S., Gene 283:49-62(2002) [PubMed: 11867212].Martin J., Nature 432:988-994(2004) [PubMed: 15616553].Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039].
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ADAMTS18.
Involvement In Disease	Microcornea, myopic chorioretinal atrophy, and telecanthus (MMCAT)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. Cal S., Gene 283:49-62(2002) [PubMed: 11867212]. Martin J., Nature 432:988-994(2004) [PubMed: 15616553]. Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039].
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ADAMTS18 protein.
Subcellular Location	Secreted, extracellular space, extracellular matrix

Uniprot	Q8TE60
Gene Id	170692
Database Links	HGNC:17110 OMIM:607512 KEGG:hsa:170692 STRING:9606.ENSP00000282849 UniGene:Hs.188746
Tissue Specificity	Expressed in fetal lung, liver, and kidney and in adult brain, prostate, submaxillary gland, and endothelium.
Weight	135kDa

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558197	CSB-PA999160	100ul	$297		Add to Cart

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