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Home / Antibodies

ACTN4 Antibody / Alpha Actinin 4 (V8177SAF)

SKU : BHA17127288

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NSJ Bioreagents

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Mfr.No.	V8177SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	The spectrin gene family encodes a diverse group of cytoskeletal proteins that include spectrins, dystrophins and -actinins. There are four tissue-specific -actinins, namely -actinin-1, -actinin-2, -actinin-3 and -actinin-4, which are localized to muscle and non-muscle cells, including skeletal, cardiac and smooth muscle cells, as well as within the cytoskeleton. Each -actinin protein contains one Actin-binding domain, two calponin-homology domains, two EF-hand domains and four spectrin repeats, through which they function as bundling proteins that can cross-link F-Actin, thus anchoring Actin to a variety of intracellular structures. Defects in the gene encoding -actinin-4 are the cause of focal segmental glomerulosclerosis 1 (FSGS1), a common renal lesion characterized by decreasing kidney function and, ultimately, renal failure.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A recombinant full-length human ACTN4 protein was used as the immunogen for this Alpha Actinin 4 antibody.
Isotype	Mouse IgG
Species Reactivity	Human
Note	Optimal dilution of the antibody should be determined by the researcher.

Uniprot	O43707

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the Alpha Actinin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/alpha-actinin-4-antibody-93-v8177" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127288	V8177SAF-100UG	100 ug	$499		Add to Cart

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