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Home / Primary Antibodies

Active Caspase-3 Monoclonal Antibody

SKU : BHA13715126

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Abbkine Scientific Co., Ltd.

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Mfr.No.	ABM0062
Background	CASP3 (caspase 3) encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of CASP3 results in two transcript variants that encode the same protein.
Clonality	Monoclonal
Description	Mouse Anti-Active Caspase-3 Monoclonal Antibody
Formulation	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen, Liquid solution
Host	Mouse
Immunogen	Recombinant Protein
Immunogen Region	Recombinant Protein
Isotype	Mouse IgG1
Molecular Weight	17 KD
Others	The antibody detects endogenous Active Caspase-3 protein.
Precautions	The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Reactivity	Human, Mouse, Rat, Chicken
Tag	Caspase-3
Note	Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:1000), IF (1:50-1:200), IHC-P (1:100-1:200).

Accession Number	P42574
Gene Id	836, 836

Concentration	1 mg/ml, 1 mg/ml
Purification	The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen, The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen
Storage Buffer	PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.
Storage Instructions	Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Applications	WB, IF, IHC-P

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA13715126	ABM0062	100 uL	$229		Add to Cart

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