Muscarinic acetylcholine receptor 1 is a muscarinic receptor. The muscarinic cholinergic receptors belong to a larger family of GPCRs. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. AChR is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids 303-317 (KMPMVDPEAQAPTKQ-human) were used as the immunogen for this muscarinic AChR antibody (100% mouse homology).
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Uniprot
P11229
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the AChR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Applications
WB, IHC-P, IHC-F, IF, ICC
Dilution
Western blot: 0.5-1ug/ml,Immunohistochemistry (FFPE & frozen): 1-2ug/ml, Immunofluorescence/Immunocytochemistry: 2-4ug/ml