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Home / Primary Antibodies

ACER2 Antibody

SKU : BHA10558210

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA293630
Alternative Names	Alkaline ceramidase 2; AlkCDase 2; Alkaline CDase 2; haCER2; EC=3.5.1.23
Categories	Primary Antibodies
Clonality	polyclonal
Description	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.Xu R., FASEB J. 20:1813-1825(2006) [PubMed: 16940153].Wan D.,Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874].Humphray S.J., Nature 429:369-374(2004) [PubMed: 15164053].
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human ASAH3L.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate. Xu R., FASEB J. 20:1813-1825(2006) [PubMed: 16940153]. Wan D.,Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed: 15498874]. Humphray S.J., Nature 429:369-374(2004) [PubMed: 15164053].
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total ASAH3L protein.
Subcellular Location	Golgi apparatus membrane, Multi-pass membrane protein

Uniprot	Q5QJU3
Gene Id	340485
Database Links	HGNC:23675 OMIM:613492 KEGG:hsa:340485 STRING:9606.ENSP00000342609 UniGene:Hs.41379
Function	Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18
Protein Families	Alkaline ceramidase family
Tissue Specificity	Highly expressed in placenta.
Weight	15,864 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558210	CSB-PA293630	100ul	$297		Add to Cart

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