This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alteatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
A portion of amino acids 1274-1306 from the human protein was used as the immunogen for this ACE antibody.
Isotype
Mouse IgG2a
Species Reactivity
Human, Mouse
Note
Titration of the ACE antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
P12821
Format
Ascites
Purity
Ascites
Storage
Aliquot the ACE antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.