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Home / Antibodies

5-Lipoxygenase Antibody (R30728)

SKU : BHA17104313

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NSJ Bioreagents

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Mfr.No.	R30728
Clonality	Polyclonal
Description	5-Lipoxygenase is an enzyme that in humans is encoded by the ALOX5 gene. It is a member of the lipoxygenase family of enzymes which also transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. The enzyme 5-lipoxygenase catalyzes 2 reactions in the formation of leukotrienes. Human ALOX5 contains three nuclear localization sequences (NLSs) and a phosphorylation site involved in nuclear localization. Compared with age-matched competent mice, the knockout mice developed less right heart hypertrophy. Pharmacologic inhibition or gene disruption resulted in a significant decrease of beta-amyloid production and gamma-secretase levels. ALOX5 activity is short-lived, apparently in part because of an intrinsic instability of the enzyme.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Rabbit
Immunogen Region	An amino acid sequence from the C-terminus of human ALOX5 (AERNKKKQLPYYYLSPDR) was used as the immunogen for this 5-Lipoxygenase antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P09917

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	After reconstitution, the 5-Lipoxygenase antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, IHC-P
Dilution	Weste blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17104313	R30728	100 ug	$419		Add to Cart

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