Transcriptional factor that binds to the consensus sequence 5'-(GT)(AG)(AGT)GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.
Categories
Primary Antibodies
Cellular Localization
Cytoplasm, Nucleus
Clonality
polyclonal
Description
Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters. Also acts as a transcription activator and promotes cancer cell progression and/or migation in various tumors and myelomas.
Host
Rabbit
Immunogen
zinc finger with KRAB and SCAN domains 3
Isotype
IgG
Molecular Weight
62 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Subcellular Location
Cytoplasm, Nucleus
Synonyms
ZKSCAN3, dJ874C20.1, KIAA0426, ZF47, ZFP306
Uniprot
Q9BRR0
Gene Id
80317
Research Area
Metabolism
Weight
62kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)